DR. DEPAEPE
HOW EXACTLY DOES THIS STEM CELL THERAPY WORK
Knie arthrose is geassocieerd met synoviale inflammatie, kraakbeen afbraak en botremodellering. Met stamcel therapie pogen we de pijn ontstaan door inflammatie onder controle te krijgen, de progressie van kraakbeen afbraak te stoppen en op die manier de gewrichtsfunctie te verbeteren. Mesenchymale stamcellen hebben het potentieel om te differentiëren tot chondrocyten.
Stem cells stimulate vascularization, cell proliferation, cell differentiation and intervene in the regulation of inflammatory processes.
Classical liposuction of abdominal fat is performed using a standardized protocol to damage the stem cells as little as possible. The liposuction aspirate is washed several times in a centrifuge until a pure aspirate can finally be obtained, which is injected intra-articularly into the knee.
WHY IS ABDOMINAL FAT USED
- Stem cells from abdominal fat show a greater capacity for proliferation than other types of mesenchymal stem cells.
- Mesenchymal stem cells are very abundant in abdominal fat.
- Simple prelevance w.r.t. bone marrow cells because subcutaneous fatty tissue in the abdomen is very easily accessible and causes much less donor site morbidity than bone marrow punctures.
FOR WHOM?
Mainly patients between 40 and 70 years of age with symptomatic gonarthrosis and radiological grade 2 and 3 arthrosis. The exclusion criteria are grade 4 cartilage disease (bone-to-bone contact), severe varus or valgus axis abnormalities, morbid obesity, co-morbidity of rheumatic disease in the knee.
WHAT ARE THE PROVEN RESULTS?
In the first studies there is a clear improvement in pain scores and function scores. There is also a clear reduction in the inflammatory response in osteoarthritis. This means a clear reduction in osteoarthritis symptoms. In some reports there is a first report of a reduction in apoptosis of the chrondrocytes, but there is no proven evidence for the reduction of disease progression. However, no side effects have been documented to date.
COST
The treatment is done as a day hospital. The surcharge for the patient varies between 350 and 450 euros.
ARTICLE IN JAN PALFIJN NEWS
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Orthopedisch chirurg – AZ Jan Palfijn Gent
Specialized in shoulder and knee surgery
De informatie op deze pagina is opgesteld door Dr. Yves Depaepe en is bedoeld als algemene medische voorlichting. Raadpleeg altijd uw arts voor een persoonlijk behandelplan.